Powder testing with the TA.XTPlus Texture Analyzer is a relatively new testing method, so as of yet we only have a handful of papers currently in publication or as upcoming poster sessions involving research conducted using the instrument. Once the papers are presented then we will offer the abstracts and their references on this site.
Improving the Physical and Chemical Properties of Ibuprofen, Aly H. Nada, Saleh M. Al-Saidan, Bernd W. Mueller,Pharmaceutical Technology Nov 2, 2005 (http://www.pharmtech.com/pharmtech/article/articleDetail.jsp?id=190346)
085 McGlinchey Abstract - Comparison of PFA to Mixsim Model.doc
A CFD analysis of the Stable Microsystems Powder Flow Analyser (PFA) with an experimental comparison
Andrew Cowell, Don McGlinchey, Ray Ansell
ABSTRACT
A recent development in the arsenal of methods of powder characterisation are the devices based on measuring the forces and torques developed when stirring a small vessel of powder with a helical blade mounted on a vertical shaft. Thus far, the ability of the machines to distinguish one powder from another and be able to rank powders on the basis of some bulk properties has been reasonably well demonstrated.
This paper is a continuation of previous work on the Powder Flow Analyser (PFA) and the ongoing efforts to improve the models based on the use of powder mechanics with traditional mechanical engineering analysis, and related to the study of helical flights in screw conveyors and impeller blades in mixers. This paper describes the use of a Computational Fluid Dynamics (CFD) package and the variation of test parameters within the PFA test protocol. This includes such variables as blade tip speed and angle of attack.
The Fluent CFD package with the MixSim add-in allows the comprehensive analysis of mixing equipment. Previous work with the PFA indicates it is possible to model the device as a “mixer”. The geometric model of the PFA was developed within MixSim and the subsequent analysis carried out within Fluent, making use of the multiphase modelling tools. The results from this model are compared to the experimental data generated by the PFA.
Papers Presented in ConferencesCentre for Industrial Bulk Solids HandlingSchool of Engineering, Science and Design, Glasgow Caledonian University, Scotland, UK.
2005 Papers
Cowell, A., McGlinchey, D., "Further investigation of the Stable Microsystems Texture Analyser (TA) as a powder characterisation tool", 7th World Congress of Chemical Engineering, 10 - 14 July 2005, Glasgow, Scotland.
New Flow Indexes to Predict Pharmaceutical Powder Flow
Behavior Using the ManUmit Powder Rheometer
Wayne Wang, Larisa Rollins, Daniel Brown
US Product Development, AstraZeneca Pharmaceuticals AAPS Annual Meeting 2003
Relating powder rheology to tablet processing characteristics, Ian. J. Hardy and Walter. G. Cook, Pharmaceutical and Analytical R & D, AstraZeneca, Bakewell Road, Loughborough, Leicestershire, United Kingdom, LE11 5RH